Chronic exposure of tobacco may responsible for pulmonary damage and for loss of elasticity in the alveoli, leading to emphysema and Chronic obstructive pulmonary disease (COPD). It can cause shortness of breath, wheezing, persistent cough with sputum, triggering asthma, and damage to the lungs, including emphysema and chronic bronchitis. COPD is one of the leading causes of death.